I am a medical scientist interested in making translatable solutions that bring advanced medical care to more people.

Healthcare technology has rapidly progressed, but many modern therapies remain unattainable for the majority of people around the world. Lack of accessibility and affordability are barriers that continue to grow with each new generation of medical technology. New devices are often substantially more costly or require so much expertise that they remain limited to only advanced medical centers.

Experience

During my time in the Edelman Lab at MIT, I studied device-organ interactions to make mechanical circulatory support more accessible for the treatment of heart failure. The results of my work are now clinically deployed as the SmartAssist platform. At MicroPort, I am driving global initiatives to bring medical devices that are effective and affordable for more sustainable healthcare around the world. At X-COR Therapeutics, we have tackled both accessibility and affordability by developing a medical device for the treatment of respiratory failure with ease-of-use and cost in mind from the beginning. By integrating with existing medical workflows and protocols, we are creating a device that can be used by more people and in more locations around the world. In the past, I have also spent time at DOE NETL.

Personal

I am a Southern California native living in Boston and am passionate about sustainable healthcare and educational outreach. I am an associate editor and peer reviewer for the Journal for Emerging Investigators, which serves as an avenue to encourage and educate the next generation of scientists through publication. I also volunteer with Boston Partners in Education as an academic mentor at Boston Arts Academy to help high school students in STEAM subjects. In my free time, I enjoy tinkering around in different programming languages, cooking, dragon boat racing, and mountaineering.

Selected Publications

Peer-reviewed

B. Y. Chang et al. A scalable approach to determine intracardiac pressure from mechanical circulatory support signals, IEEE Trans. on Biomedical Engineering (2020).

S.P. Keller* and B. Y. Chang* et al. Dynamic Modulation of Device-Arterial Coupling to Determine Cardiac Output and Vascular Resistance, Annals of Biomedical Engineering (2020).

N. L.J. Udesen et al. Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock, Critical Care (2020).

B. Y. Chang, S. P. Keller. Dual Carbon Dioxide Capture to Achieve Highly Efficient Ultra-Low Blood Flow Extracorporeal Carbon Dioxide Removal, Annals of Biomedical Engineering (2020).

B. Y. Chang*, S. P. Keller*, E. R. Edelman. Leveraging device-arterial coupling to determine cardiac and vascular state, IEEE Transactions on Biomedical Engineering (2019).

B. Y. Chang et al. Mechanical circulatory support device-heart hysteretic interaction can predict left ventricular end diastolic pressure, Science Translational Medicine, 2980 (2018).

K. Pekkan, et al. Characterization of zebrafish larvae suction feeding flow using uPIV and optical coherence tomography, Experiments in Fluids, 57, 1-7 (2016).

N. S. Siefert, B. Y. Chang, S. Litster. Exergy and economic analysis of a CaO-looping gasifier for IGFC-CCS and IGCC-CCS, Applied Energy, 128, 230-245 (2014).

Patents

Systems and methods for determining cardiac performance, US16446419.

Systems, devices, and methods for extracorporeal removal of carbon dioxide, WO2019055933A2.

Cardiovascular assist system that quantified heart function and facilitates heart recovery, US10376162.