Brian Y. Chang

bychang@pm.me |

I help build medical devices that bring better medical therapies to more people.

Experience

At Miracle Point we evaluate and develop new emerging medical technologies through a proven pipeline to reach commercialization. I have previously spent time in the Edelman Lab at MIT, where I studied device-organ interactions to make mechanical circulatory support more accessible for the treatment of heart failure. The results of my work are now clinically deployed as the Impella SmartAssist. At X-COR Therapeutics, I helped develop a new medical device for the treatment of respiratory failure with ease-of-use and accessible cost in mind from its inception. In the past, I have also spent time at DOE NETL.

Education

MD Harvard Med
PhD MIT
MS/BS Carnegie Mellon

Personal

I am based in Boston, MA and am passionate about MedTech development for sustainable healthcare. In my free time, I enjoy dragon boat racing, mountaineering, and spending time with my dog.

Selected Publications

Articles

B. Y. Chang et al. Hysteretic device characteristics indicate cardiac contractile state for guiding mechanical circulatory support device use, Intensive Care Medicine Experimental (2021).

B. Y. Chang et al. A scalable approach to determine intracardiac pressure from mechanical circulatory support device signals, IEEE Trans. on Biomedical Engineering (2020).

S.P. Keller* and B. Y. Chang* et al. Dynamic Modulation of Device-Arterial Coupling to Determine Cardiac Output and Vascular Resistance, Annals of Biomedical Engineering (2020).

N. L.J. Udesen et al. Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock, Critical Care (2020).

B. Y. Chang, S. P. Keller. Dual Carbon Dioxide Capture to Achieve Highly Efficient Ultra-Low Blood Flow Extracorporeal Carbon Dioxide Removal, Annals of Biomedical Engineering (2020).

B. Y. Chang*, S. P. Keller*, E. R. Edelman. Leveraging device-arterial coupling to determine cardiac and vascular state, IEEE Trans. on Biomedical Engineering (2019).

B. Y. Chang et al. Mechanical circulatory support device-heart hysteretic interaction can predict left ventricular end diastolic pressure, Science Translational Medicine, 2980 (2018).

K. Pekkan, et al. Characterization of zebrafish larvae suction feeding flow using uPIV and optical coherence tomography, Experiments in Fluids, 57, 1-7 (2016).

N. S. Siefert, B. Y. Chang, S. Litster. Exergy and economic analysis of a CaO-looping gasifier for IGFC-CCS and IGCC-CCS, Applied Energy, 128, 230-245 (2014).